Candida albicans is a dimorphic type of yeast; this means it exists in two different forms. The less pathogenic form does not have tendrils; and, merely exists as a cell—this is called its blastoconidia form. However, Candida albicans can become more aggressive; and, develop long tendrils (or germ tubes) known as hyphae. These tendrils can burrow into your skin. This allows the fungus to gain a greater foothold in your body; and, acquire more nutrients to grow.
A study published in the journal Virulence [2013 Feb 15; 4(2): 119–128] showed that Candida albicans has a tendency to grow hyphal germ tubes when the pH of its environment is high; about a 7 on the pH scale. Lower pH levels, are also able to keep Candida albicans in its blastoconidia budding yeast form, which is less pathogenic. Candida of all kinds prefer a more alkaline environment; and, keeping an envrionment’s pH low, will also discourage its overall growth. For women with a yeast infection, it is wise to use a pH balancing tampon or a menstrual pad, instead of a regular tampon. Having a tampon in place will allow blood (which has a higher pH) to dilute the vagina, and raise the natural pH of the vagina to undesirable levels. The study, which addressed tampon usage in the presence of yeast overgrowth, was published in the International Journal of Gynecology and Obstetrics [85.3 (2004): 298-300].
Aside from growing of hyphal germ tubes, Candida species also pose greater threat to you via becoming drug resistant and their formation of biofilm. As we will discuss, these two things are probably the reason over the counter, or prescription azole drugs (such as fluconazole), are not getting rid of your yeast infection—for those of you who are not seeing immediate results, that is.
Candida with Biofilm: 1000 Times More Resistant
One study, that reported some interesting findings, was published in the Journal of Antimicrobial Chemotherapy [(2012) 67 (3): 618-621]. The study found that Candida, when it has formed a biofilm, was about 1024 times more resistant to conventional antifungal drugs. This may explain why, if you haven’t seen results from conventional azole antifungal drugs, your yeast infection isn’t being cured after drug therapies.
Biofilm is a layer of sludge that yeast cells sometimes form to protect themselves. Biofilm formation is a common feature of certain microbiological organisms. Below is a picture taken from this study showing the development and growth of Candida albicans biofilm. As the picture shows, this film effectively inhibits Candicidal materials from even coming in contact with the actual fungus; giving it over a thousand times more resistance to drugs. The larger picture shows the rounded yeast cells, and the hyphal (germ tube) growths of Candida albicans. In the photo, C. albicans was allowed to develop for 48 hours of time; whereby it began to produce a biofilm. You can notice how the yeast is beginning to become covered with a sludge; and, distinct rounded and elongated cells are not as distinguished. The white arrow, in the larger picture indicates exopolysaccharide material. Exopolysaccharides are a polymer (a large molecule; plastics are polymers) of sugar. Some microorganisms create these sugar polymers to form biofilm. In the smaller (a, inset) picture, the white arrow indicates the smooth cell membrane of a normal cell.
Fortunately, natural remedies such as herbs and essential oils can drastically reduce the ability of biofilm to protect Candida. The study in the Journal of Antimicrobial Chemotherapy [(2012) 67 (3): 618-621] found that cinnamon essential oil was capable of killing Candida that had pre-formed biofilms. And, the natural cinnamon oil, was also able to increase the effectiveness of antifungal drugs; making it a great addition to any prescription drug you may be taking. Other essential oils and herbs, can probably be of great use for combating Candida, as they could help break up protective biofilm. If you’d like to read a bit more about how cinnamon can treat stubborn yeast infections, consider perusing this article: Cinnamon Essential oil for Yeast Infection.
Drug Resistance and Candida Infections
Candida does have the ability to rapidly acquire drug resistance. This means, that changes occur in cellular metabolism, which make typically effective substances of no use in killing Candida. A study conducted on the second leading species of Candida to infect people, Candida glabrata, examined how rapidly this fungus would develop resistance to fluconazole. The study was published in the journal Antimicrobial Agents and Chemotherapy [February 2005 vol. 49 no. 2 pp. 783-787]. The study found that Candida glabrata developed significant fluconazole resistance within just 4 days of being exposed to this drug.
If you have had repeat yeast infections, and have been using antifungal drugs, the yeast could have become resistant to these medications. If you are simply not seeing results with synthetic chemicals, you should investigate natural remedies that are proven to kill even drug resistant strains of Candida.
Natural 12 Hour Cure for Candida Infections
One woman, Sarah Summer, probably had both hyphal germ tubes and biofilm growing on the inside of her vagina. This was the final stage her recurrent yeast infection situation developed into before she turned to natural remedies. Summer heard from her doctor that this advanced yeast infection she had was simply untreatable. This was a devastating thing to hear; thinking you may have to face a life with a consistent vaginal yeast infection!
Instead of giving up hope and just living with her condition, Sarah Summer, and her husband Robert, began investigating medical journals and research related to her situation. After some ardent research Sarah was able to finally arrive at a powerful treatment. The difference between the old ways she had treated her infection and the new way was simple: a focus on the root causes of infection. After trying seemingly everything, this new solution totally healed Sarah and she is still free of yeast infections to this day.
Sarah Summer uses all-natural medicine that you can safely use in the comfort of your own home. Summer has published her findings in a book that you can download from her U.S. based publisher (a subsidiary of Keynetics Incorporated). Summer knows how efficacious her treatment is, able to clear up a yeast infection in just 12 hours, and guarantees her work with an 8-week 100% money back guarantee. Thus the book is safe to try, and you can be assured of getting your money back promptly if you deem her work unsatisfactory!
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- http://dx.doi.org/10.1016/j.ijgo.2004.03.003 — Efficacy of a novel pH-buffering tampon in preserving the acidic vaginal pH during menstruation. International Journal of Gynecology & Obstetrics [85.3 (2004): 298-300]. PDF Available Here
- http://dx.doi.org/10.4161/viru.22913 — Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence [2013; 4(2):119-128] Full Text Available Here
- http://dx.doi.org/10.1093/jac/dkr512 — Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms. Journal of Antimicrobial Chemotherapy [(2012) 67 (3): 618-621]
- https://dx.doi.org/10.1128/AAC.49.2.783-787.2005 — Rapid Acquisition of Stable Azole Resistance by Candida glabrata Isolates Obtained before the Clinical Introduction of Fluconazole. Antimicrobial Agents and Chemotherapy [February 2005 vol. 49 no. 2 p. 783-787]