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Lactobacillus acidophilus for Oral Thrush

Using L. acidophilus as a Natural Treatment for Oral Thrush

 

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L. acidophilus can be used to make homemade yogurt. Homemade yogurt with living L. acidophilus bacteria should be a viable natural remedy for oral thrush.
L. acidophilus can be used to make homemade yogurt. Homemade yogurt with living L. acidophilus bacteria should be a viable natural remedy for oral thrush.

Oral thrush is a condition that can be helped by the probiotic Lactobacillus acidophilus (L. acidophilus). Research verifies that L. acidophilus is a viable natural treatment for oral thrush, and we will discuss various studies that provide a basis for this conclusion.

Oral thrush is a form of candidiasis; and, candidiasis is caused by the genus of yeast Candida. Candida are commensal organisms and common members of the microflora of humans. A commensal organism is one that derives a benefit from its host without causing harm. In addition to being a commensal, Candida species are also opportunistic pathogens; i.e., they attack when presented with an opportunity to do so (Romo et al.; 2020).

Taking antibiotics can lead to one opportunity for Candida to overgrow: a lack of bacterial competition. When bacteria are not around to consume resources and take up binding sites, Candida can take advantage of this opportunity and overgrow. The result is a yeast infection (oral thrush if it occurs in the mouth).

Other opportunities include situations where the immune system is compromised; e.g., cancer or HIV. These situations allow the normally commensal Candida to proliferate and cause an infection.

L. acidophilus can help to cure an oral thrush infection. Possibly the way this is done is by consuming resources, adhering to binding sites in the mouth (thereby preventing Candida cells from attaching to these locations), and perhaps by secreting lactic acid—as Candida prefer a more alkaline environment. However the exact method of action occurs, it is an established understanding that Candida does not thrive well in the presence of L. acidophilus.

Candida Hub has an entire article dedicated to L. acidophilus and why it is a good treatment for yeast infections. As oral thrush is actually a yeast infection of the mouth, it may be something to peruse for further information. The link to this article is presented below.

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Research Concerning L. acidophilus & Oral Thrush

Pictured here is L. acidophilus. This bacteria is an important probiotic that can be found in health food stores the world over. Research shows it is a capable treatment for oral candidiasis. Image Source: Muhammad, Zafarullah, et al. (2021).
Pictured here is L. acidophilus. This bacteria is an important probiotic that can be found in health food stores the world over. Research shows it is a capable treatment for oral candidiasis. Image Source: Muhammad, Zafarullah, et al. (2021).

The first study we will examine was published in Oral Diseases [23.7 (2017): 919-925]. The study looked at how a probiotic cheese, containing L. acidophilus or L. rhamnosus, affected oral Candida colonization in denture wearers. This study will show us how well the introduction of probiotics into the mouth will combat oral Candida colonization.

The study states that complete denture (complete dentures are removable devices used when all teeth within a jaw have been lost and need to be prosthetically replaced) wearers are more prone to develop oral candidiasis. Complete denture wearers also have higher rates of prevalence for Candida species compared to those who do not use these devices.

Furthermore, the study states that probiotic bacteria are living microorganisms that, when given in sufficient amounts, provide a health benefit to the host. Previous information shows the use of probiotics may prevent, or treat, candidiasis. In vitro (in a test environment) and in vivo (in living subjects) studies have shown the inhibitory ability of probiotics against Candida.

This research was conducted with 60 participants who wore complete dentures. The criteria to be included in the study involved having oral Candida colonization and the absence of clinical signs of denture stomatitis or Candida infection. It should be noted, you can have Candida colonizing a body area without it causing an infection in that area.

We can perhaps infer, from the above graph, that cheese without probiotics (group C) makes somewhat of a difference in oral Candida colonization. This may be due to the bacterial metabolites and any other chemicals regular cheese bacteria create—it could have a slight inhibitory effect on Candida.

The study concluded that daily consumption of probiotic cheese, with either L. acidophilus or L. rhamnosus, was capable of reducing the oral colonization of Candida in people who wore complete dentures. The study stated that this finding suggests these probiotics have potential to lower the risk of oral thrush in complete denture wearers.

More on Dentures & Probiotics

The next study we will discuss investigated the short term effect of probiotics (including L. acidophilus) in lowering the infection level of oral Candida in elderly denture wearers. The study was published in the Journal of Prosthodontics [24.3 (2015): 194-199].

The study was conducted with 59 denture wearers that had Candida species in their mouths and had no clinical symptoms of infection. These subjects were allocated into two groups: a probiotic group and a placebo group.

All of the subjects were instructed to clean their dentures daily before pouring the capsules onto the dentures. The subjects in the probiotic group poured a capsule containing freeze dried probiotics on the palatal surface of the maxillary denture on a daily basis. The probiotics in the capsules were L. acidophilus, L. rhamnosus, and Bifidobacterium bifidum. The placebo group followed the same protocol, but used placebo capsules. The subjects in the study performed this protocol daily for 5 weeks.

The infection levels of Candida species were evaluated in palate mucosa (mucosa are mucous membranes, e.g., the soft tissue that lines the inside of the mouth) samples that were taken before and after a 5 week period.

Concerning the results of the experiment, 55 subjects completed the experimental period. The study found that the placebo group had a detection rate for Candida of 92% after the 5 week period. Comparatively, the probiotic group’s Candida detection rate was reduced to just 16.7%.

The study concluded that the freeze dried probiotic capsules were effective in reducing the colonization of the mouth by Candida. These results suggested that a multi-species probiotic could be used to prevent oral candidiasis.

L. acidophilus Clears Away Candida

The next study we will investigate was published in Clinical & Experimental Immunology [141.1 (2005): 29-36]. The study looked at how well L. acidophilus would work to remove C. albicans from the mouth of mice. This study may be able to be extrapolated to get some degree of understanding of the situation in humans.

This research paper states probiotic bacteria have been used extensively within the food industry; especially in milk products. The claims of probiotic promotion of host defenses have been supported by various reports. This study was developed to analyze the mechanism of protection induced by orally administered Lactobacillus species of bacteria.

To achieve this, mice were fed Lactobacilli (one species was L. acidophilus) every day for 2 weeks. Other mice, serving as controls, were not fed Lactobacilli. One day after the last feeding, all the mice were orally inoculated with C. albicans. Feeding of the mice continued for 6 or 14 days.

The study found that mice who were fed L. acidophilus showed a rapid decline in the colonization of the mouth by C. albicans. A day after the start of the experiment, the number of C. albicans cells in mice not fed L. acidophilus were similar to the mice fed L. acidophilus.

On day 2 of the experiment a rapid decline in the colonization levels of C. albicans in the mice fed L. acidophilus was seen. By day 6 of the study the mice fed L. acidophilus had undetectable numbers of yeast in their mouths. The protective effect of L. acidophilus against C. albicans was seen in the mice 2 weeks after the oral feeding of L. acidophilus was halted.

Another study also looked at how L. acidophilus would affect experimentally induced oral candidiasis in mice. This study was published in Oral Diseases [18.3 (2012): 260-264]. Again, this may be able to be extrapolated to some degree; and thus applied to how humans may react.

The study used a strain of C. albicans to induce the oral infection. The animals were orally inoculated with the yeast cells and then given either nystatin or probiotics (L. acidophilus / L. rhamnosus).

There were three treatment groups in the experiment conducted on the mice. Group 1 was given the antifungal drug nystatin. Group 2 was given L. acidophilus. And, the third group was given L. rhamnosus. In each of these treatment groups some animals were allocated into a control group that did not receive treatment at all.

The group receiving nystatin started this drug 1 day after the experimental inoculation with C. albicans. Treatment with nystatin occured daily and lasted for 13 days.

The groups receiving either of the probiotic bacteria started receiving the specified probiotic 2 weeks before being inoculated with C. albicans. The probiotic treatment occurred daily and lasted for 27 days. The mice were given the probiotics in their mouths.

The mice were then evaluated at various days after inoculation. The chart below details the findings of this experiment. You can see in the graph, the upward pointing triangle icon represents mice treated with L. acidophilus. The downward pointing triangle represents mice given L. rhamnosus. Both probiotics appeared to protect the mice better than nystatin (shown in the circle icon).

This chart shows the compares how C. albicans colonized mice that were treated with L. acidophilus (△), L. rhamnosus (▽), Nystatin (○), or serving as controls without a treatment (◻). Both L. acidophilus and L. rhamnosus appear to have prevented C. albicans growth better than nystatin.
--Click to Enlarge--
This chart shows the compares how C. albicans colonized mice that were treated with L. acidophilus (△), L. rhamnosus (▽), Nystatin (○), or serving as controls without a treatment (◻). Both L. acidophilus and L. rhamnosus appear to have prevented C. albicans growth better than nystatin.

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Literature about L. acidophilus for Oral Thrush

Taking broad-spectrum antibiotics can kill off even good probiotic bacteria in the body. This can pave the way for Candida (which is a fungus and isn’t hurt by these drugs) to overgrow and cause infection.
Taking broad-spectrum antibiotics can kill off even good probiotic bacteria in the body. This can pave the way for Candida (which is a fungus and isn’t hurt by these drugs) to overgrow and cause infection.

Sears et al.; in their book The Baby Book, Revised Edition; discuss using L. acidophilus as a home remedy for babies with oral thrush. According to this text, a simple home remedy for oral thrush is L. acidophilus powder. In addition to medication for this condition, the authors suggest spreading a finger-tip-full of L. acidophilus powder on the oral thrush infection twice a day for a week.

Joiner-Bey et al., in their book The Clinician’s Handbook of Natural Medicine - E-Book, discuss using L. acidophilus for oral thrush for people with HIV / AIDs. Yet, this advice can probably be readily transferred to all people. The authors suggest taking a dose of probiotics of 8 billion CFU with food. The probiotic species suggested include L. acidophilus, L. rhamnosus, L. casei, L. bifidus, and Saccharomyces boulardii.

As oral thrush can often be a superinfection (reinfection or a second infection with a microbe), a book discusses L. acidophilus for these infections. The book is by Froum et al. and titled The Dentist’s Drug and Prescription Guide. In chapter 4 of the book, under the section "I. Antimicrobials, systemic," superinfections are discussed.

The question is posed by the book, "What adverse effects can occur with antibiotics that you need to warn the patient about and how is it managed?"

The answer to this question is that antibiotics, especially broad-spectrum antibiotics, change the microbial life of the stomach. This results in diarrhea and fungal infections. This occurs with antibiotics because the bacteria are killed off and allows for the growth of Candida species.

To help avoid such bacterial complications, the book suggests that all patients, especially women, eat yogurt with live and active cultures. To prevent antibiotic induced superinfections, about 5 ounces of yogurt should be eaten twice a day while undergoing antibiotic therapy.

The book also suggests that an alternative to eating yogurt with live cultures is to take L. acidophilus supplements.

The book states a side effect of taking L. acidophilus may be slight bloating for the first few days or weeks taking the supplement; yet, this does not usually last. The book states that the term acidophilus is often used to refer to a combination of L. acidophilus with other beneficial bacteria. This text may have meant the broader definition when using the term acidophilus in this section of the book.

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A Natural, 12 Hour Oral Thrush Remedy

Linda Allen’s Yeast Infection No More

As you may know, Candida causes more than just oral thrush. Yeast infections of all kinds are induced by this ubiquitous pathogen. And, in certain individuals, a systemic infection can occur. Candida colonizes the digestive system; and, can spread to other parts of the body from there. The result of this fungus proliferating in the body is a host of unusual health problems. Too much Candida in the digestive system, in severe cases, can even induce drunkenness when a person eats a carbohydrate rich meal (Candida creates alcohol as a by-product of its metabolism).

One woman who suffered with systemic candidiasis, and recurrent yeast infections, was Linda Allen. Linda was plagued with unusual health problems for about 12 years as a result of Candida.

Linda’ troubles with Candida began in her late teen years. During the winter Linda developed a sinus infection that appeared to be incurable. Shortly thereafter she came down with a vaginal yeast infection.

Linda visited a doctor about her health and was prescribed antibiotics. The first course of these drugs appeared to not work, and she was prescribed even stronger antibiotics. These drugs would seem to work for only a few weeks; yet, afterwards Linda’s symptoms returned. The doctor would eventually try putting her on allergy medication, but nothing seemed to work.

Although Linda was struggling with a chronic yeast infection, she did not know it. Her symptoms included vaginal discharge, burning sensations, and terrible itching. This was all a difficult experience for a young woman. Linda stated that yeast infections can become very difficult to live with when they happen as often as your menstrual period.

Linda ended up investing a lot of her financial means on medical bills. Linda’s family even helped her out with her medical bills; and this left them without much money to spare.

Linda’s life changed for the better when she visited a naturopath about her situation. The naturopath knew exactly what was wrong with her: systemic candidiasis.

Armed with this knowledge, Linda devoted a lot of time and effort to understanding Candida and the various ways to treat it. Eventually, Linda developed a natural protocol that she hoped would get rid of her Candida problem.

After spending about a year refining her new approach, she tried it on herself. The results were simply amazing. It was not long before Linda’s health improved. Eventually she became totally free of superficial yeast infections and her systemic Candida. She was finally feeling healthy at last!

Linda went on to write an explanatory book detailing her natural system for curing yeast infections and systemic Candida. In this book, Linda also provides a novel, natural, 12 hour yeast infection treatment. This treatment will remedy an oral thrush infection in about half a day. And, Linda’s system can stop Candida infections for recurring.

Linda’s book is published by a prominent digital retailer—a subsidiary of the United States based firm Keynetics Incorporated. Linda’s publisher provides a 60 day, 100% money back guarantee on her book. So, you can try it without risk.

Linda’s book is available as an ebook so you can download it instantly and start using it today. Since it is so easy to get her book right away, this should be more than enough time (you’ll have 60 days to request a refund) to see the efficacy of Linda’s natural 12 hour cure and treatment plan.

To learn more about Linda’s personal journey to recovery from Candida, to see testimonials of others who gave her treatment plan a try, or to find out more about her book; you can find more information at Linda Allen’s website.

Author: Mr. Nicholas Gross

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Nick Gross is a natural medicine enthusiast who has been researching and writing about natural medicine since 2008. Nick is primarily a web developer but also researches and authors written and video content about natural health. Nick has a bachelor’s degree in Management Information Systems from the University of Northern Iowa.

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SOURCES:

  • https://doi.org/10.3390/jof6010016 — Romo, Jesus A., and Carol A. Kumamoto. "On commensalism of Candida." Journal of Fungi [6.1 (2020): 16].
  • https://doi.org/10.1111/odi.12669 — Miyazima, Tatiana Yuriko, et al. "Cheese supplemented with probiotics reduced the Candida levels in denture wearers—RCT." Oral Diseases [23.7 (2017): 919-925].
  • https://doi.org/10.1111/jopr.12198 — Ishikawa, Karin H., et al. "A multispecies probiotic reduces oral Candida colonization in denture wearers." Journal of Prosthodontics [24.3 (2015): 194-199].
  • https://doi.org/10.1111/j.1365-2249.2005.02811.x — Elahi, S., et al. "Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus." Clinical & Experimental Immunology [141.1 (2005): 29-36].
  • https://doi.org/10.1111/j.1601-0825.2011.01868.x — Matsubara, Victor Haruo, et al. "Treatment with probiotics in experimental oral colonization by Candida albicans in murine model (DBA/2)." Oral Diseases [18.3 (2012): 260-264].
  • Google Books — Sears, J., Sears, R. W., Sears, W., Sears, M. . “The Baby Book, Revised Edition: Everything You Need to Know About Your Baby from Birth to Age Two.” United States: Little, Brown. (2013)
  • Google Books — Joiner-Bey, H., Pizzorno, J. E., Murray, M. T.. “The Clinician’s Handbook of Natural Medicine - E-Book.” United Kingdom: Elsevier Health Sciences. (2008)
  • Google Books — Froum, S. J., Weinberg, M. A. “The Dentist’s Drug and Prescription Guide.” United Kingdom: Wiley. (2012)
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592972/ — Muhammad, Zafarullah, et al. "Assessment of In Vitro and In Vivo Bioremediation Potentials of Orally Supplemented Free and Microencapsulated Lactobacillus acidophilus KLDS Strains to Mitigate the Chronic Lead Toxicity." Frontiers in Bioengineering and Biotechnology 9 (2021).
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