Undecylenic acid for Candida infections is an effective cure you can employ. This fatty acid has the capabilities of slowing down Candida growth and interferes with other things Candida does to maintain its grip on a person. Typically undecylenic acid has been traditionally used to treat various forms of fungal infections. It is relatively safe and you can use it along with other fatty acids to perhaps increase your remedy’s healing efficacy! You might want to include it with coconut oil to help give yeast a more powerful blow where you're having a yeast infection. Although generally safe, too much undecylenic acid can cause irritation to the skin as a side effect. If you want to see how you will react to it, you can try putting a small amount on your skin and see how your skin reacts.
Candida & Undecylenic Acid Research
Hyphal growth, the transformation from a single celled yeast into a long germ tube, has been shown to greatly contribute to the virulence of Candida. Some types of Candida are not dimorphic; i.e. exist in two different physiological forms. Yet, Candida albicans, the yeast responsible for about 80% of all infections, does develop hyphal germ tubes (Fidel, et al., 1999). Consequently, this hyphal transition Candida albicans can go through is of importance--as so many infections are a result of this one, particularly virulent, species. Some rare mutants of Candida albicans do not grow hyphae and are accordingly less virulent (Cutler, 1991).
One study analyzed how undecylenic acid would affect the development of 3 different strains of Candida albicans. The study was published in the journal Antimicrobial Agents and Chemotherapy [44.10 (2000): 2873-2875]. The researchers found that a concentration of undecylenic acid that was not strong enough to kill the yeast could in fact greatly reduce the morphological change from yeast to hyphal germ tubes. Just 10 micromoles (which is about 3.7 milligrams) of undecylenic acid reduced the presence of germ tubes by seven fold. 20 micromoles of undecylenic acid nearly eliminated hyphal growth by the yeast strain. The chart below shows on the left the percentage of hyphal growth in relation to micrograms of undecylenic acid. On the right, the chart shows the growth rate of the Candida albicans strain in varying concentrations of undecylenic acid. Note that although low concentrations of undecylenic acid inhibited hyphal growth, the overall multiplication of the yeast was not inhibited at all by these levels of the fatty acid.
Another study, published in Archives of Biochemistry and Biophysics [7.3 (1945): 415-425], reported that a small percentage concentration of undecylenic acid in a pH of 6.5 could inhibit the development of Candida albicans. This study reported that a 0.007 percent concentration of undecylenic acid inhibited Candida albicans.
Another study examined how pH levels would affect undecylenic acid’s ability to inhibit the development of Candida albicans. This study was published in the Journal of Bacteriology [78.6 (1959): 788]. The study found that a pH of 4.0 to 6.0 had little effect on undecylenic acid’s fungicidal ability; and, that the free acid--not a salt containing the acid--was better able to ward of fungi at higher pH levels. Overall, at a pH of 4.0 to 6.0, about 200 mcg / mL was a high enough concentration to successfully inhibit Candida albicans.
These previous two studies were both old; and, prior to 1995, all hyphae growing Candida species were referred to as “Candida albicans.” So there is a chance that the species they were studying in their research was not actually the albicans species of Candida.
One more current study, published in 2008 in the journal Antimicrobial Agents and Chemotherapy [52.7 (2008): 2442-2448], showed that undecylenic acid was a rather weak inhibitor of several different Candida species. The study presented an in-depth chart showing the concentration of various substances to inhibit Candida 50%, concentration to inhibit Candida 100%, and the concentration required to kill various Candida species. As you will see in the chart, undecylenic acid was not very capable of inhibiting or killing nearly all of the Candida species. And, the chart does show the results for quite a few different strains of Candida albicans. To clear up some confusion, 542.7 micromoles (the maximum amount of undecylenic acid used in the study) were used in 200 microliters of solution. This means that 542.7 micromoles is almost exactly 100 milligrams of the substance, and this was dissolved in the 200 microliters of solution (also, micromoles is abbreviated this way: μM). The researchers in the study had this to say about undecylenic acid--which they abbreviated UDA:
UDA is the only compound within the fatty acid class that is used as a topical antifungal drug for the treatment of dermatomycosis as well as oral thrush and denture stomatitis... The antifungal mechanism of fatty acids may involve interference with fungal fatty acid biosynthesis. The advantage of UDA is its low toxicity and favorable safety profile; its shortcoming is its low cure rate due to its weak antifungal potency, as shown by the weak in vitro activity against the tested pathogens in Table 2, especially when compared to TRB, a powerful fungicidal drug for the treatment of dermatomycosis (with adverse events in 10.5% of the recipients).
Another more recent study, published in 2012 in the Journal of Dental Research [91.10 (2012): 985-989], also studied undecylenic acid and its effects on Candida biofilm. In the study, two strains each of Candida albicans and Candida glabrata were used. The study, surprisingly, found that a minimum inhibitory concentration (MIC) of undecylenic acid for both species of Candida was approximately 256 mcg / mL. The minimum fungicidal concentration (the amount necessary to kill the organism) of undecylenic acid for both species was 512 mcg / mL. This seeming discrepancy between this study and the Antimicrobial Agents and Chemotherapy [52.7 (2008): 2442-2448] study could be a result of the amount of time undecylenic acid was allowed to interact with the Candida species. The Journal of Dental Research [91.10 (2012): 985-989] study analyzed the development of Candida species for up to 7 days; and, they reported that undecylenic acid’s activity against the Candida species wore off at about 8 hours after it was introduced to the yeast.
The Journal of Dental Research [91.10 (2012): 985-989] study went on to report that undecylenic acid was able to reduce the volume of Candida albicans biofilm and the thickness of the biofilm. However, Candida glabrata showed a slight increase in biofilm volume and thickness in the presence of undecylenic acid. Since undecylenic acid works to interrupt hyphae formation, and Candida glabrata does not grow hyphae, this may play some role in the difference of reaction to the fatty acid. The following chart was taken from this study and shows how both species of Candida reacted to the presence of undecylenic acid.
3 studies reported that undecylenic acid was capable of inhibiting the growth of Candida albicans. The study that did not find too much efficacy in this fatty acid’s inhibition ability may have had shorter incubation times; leading to a reduction in the efficacy of inhibition ability. Either way, it is probably safe to assume that undecylenic acid will help to stop the growth to some extent of yeast in the gut or vagina. Even the Antimicrobial Agents and Chemotherapy [52.7 (2008): 2442-2448] study did report a concentration of undecylenic acid that inhibited growth of Candida strains by 50%. Thus, this fatty acid should be able to put a stop on Candida albicans, likely the species causing your problems, to some extent when you use it.
Both Chandra, et al. (2001) and Khan (2012), in their studies involving Candida biofilm, show how drastically biofilm presence reduces the yeast’s susceptibility to various drugs and natural substances. According to the researchers, biofilm can increase the resistance of Candida to a prescription drug by 1024 times. Even an essential oil, which was able to cure Candida with biofilm much better, could be impacted by the presence of biofilm. Consequently, since Candida albicans biofilm can be reduced by undecylenic acid, it is likely a great choice for any program involving getting rid of a yeast infection.
Finally, hyphal growth of various Candida species contributes greatly to its virulence and ability to enter the bloodstream. It can be a key reason why a gut yeast infection can lead to a vast array of hazardous health problems. Stopping the hyphal growth of Candida can help to mitigate the problem wherever it is being caused in the body. This is another great reason why you should incorporate this fatty acid into your treatment plant. As science shows, undecylenic acid is quite safe to use and therefore there are little risks of side effects when using this fatty acid to heal yourself!
An All Natural 12 Hour Cure for Candida
If you have been looking around for natural cures for a yeast infection, you may have heard about Sarah Summer. Sarah herself was a victim of repeated vaginal yeast infections. When she treated herself with various products they initially cured her; however, it was only a short time before she got yet another yeast infection! This may be by design, it makes some financial sense to try and keep people buying your product--if you solve their problem, you loose them as a customer.
This cycle, as you may have experienced, went on for some time. Until, Sarah found herself plauged with a particularly severe vaginal yeast infection. Concerned, she quickly went to her doctor for advice and help with this recent infection. When her doctor examined her, she was told that her vagina had a mould in it, and that the yeast had grown deep tendrils into her body. The doctor said that not only was this infection hard to treat, it was not capable of being eliminated. Faced with a potentially unending problem that would greatly affect her life, Sarah decided to see what she could find out herself.
Together with her husband Robert, the two began to diligently study academic information regarding her condition. According to Sarah, she practically “lived” in the medical library. Fortunately, the two were excellent researchers and uncovered a powerful solution to Candidiasis. The key to this new system was dealing with the root causes of yeast infections--not merely trying to do away with surface level symptoms. When Sarah employed her new treatment, she was finally able to cure her vaginal yeast infection! And, her yeast infections stayed gone--no more recurrent infections ruining her life.
Sarah shared her results with others and they began reporting that their yeast problems were totally resolved in 12 hours. Sarah decided to publish a book showing others how to get rid of their yeast infection naturally in 12 hours. Her book shows you how to use natural items to completely heal your yeast infection; you may need to make a trip to the grocery store though! She has since received many letters of thanks for helping people with their Candida problems.
Sarah’s book is published by a subsidiary of Keynetics Incorporated; a large U.S. firm based in Boise Idaho. Sarah Summer also offers a generous 8 week, 100% money back guarantee on her book. So, if you're worried it might not work for you, you have a full 8 weeks to test it out; and, you should know in under a day if it indeed does solve your problem or not! Her book is available for instant download as a PDF, and if you would like to try it out, you can have it downloaded in no time! For more information on Sarah Summer, her book, or other’s testimonies about her product, you can find out more at Sarah Summer’s website.
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88907/ -- Fidel, Paul L., Jose A. Vazquez, and Jack D. Sobel. "Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans." Clinical microbiology reviews 12.1 (1999): 80-96. PDF Available Here
- http://dx.doi.org/10.1146/annurev.mi.45.100191.001155 -- Cutler, Jim E. "Putative virulence factors of Candida albicans." Annual Reviews in Microbiology 45.1 (1991): 187-218. PubMed
- http://dx.doi.org/10.1128/AAC.44.10.2873-2875.2000 -- McLain, Nealoo, et al. "Undecylenic acid inhibits morphogenesis of Candida albicans." Antimicrobial agents and chemotherapy 44.10 (2000): 2873-2875. PDF Available Here
- http://www.cabdirect.org/abstracts/19521300619.html -- Wyss, O., B. J. Ludwig, and R. R. Joiner. "The fungistatic and fungicidal action of fatty acids and related compounds." Archives of Biochemistry and Biophysics 7.3 (1945): 415-425.
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC290633/ -- Prince, Herbert N. "Effect of pH on the antifungal activity of undecylenic acid and its calcium salt." Journal of bacteriology 78.6 (1959): 788. PDF Available Here
- http://dx.doi.org/10.1128/AAC.01297-07 -- Li, Xing-Cong, et al. "Potent in vitro antifungal activities of naturally occurring acetylenic acids." Antimicrobial agents and chemotherapy 52.7 (2008): 2442-2448. Full Text Available Here
- http://dx.doi.org/10.1177/0022034512458689 -- Gonçalves, L. M., et al. "Effects of undecylenic acid released from denture liner on Candida biofilms." Journal of dental research 91.10 (2012): 985-989. PDF Available Here
- http://dx.doi.org/10.1016/j.jep.2012.01.045 -- Khan, Mohd Sajjad Ahmad, and Iqbal Ahmad. "Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans." Journal of ethnopharmacology 140.2 (2012): 416-423.
- http://dx.doi.org/10.1128/JB.183.18.5385-5394.2001 -- Chandra, Jyotsna, et al. "Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance." Journal of bacteriology 183.18 (2001): 5385-5394.
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