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Leaky Gut Syndrome and Candida Yeast

How Yeast Cause Leaky Gut Syndrome

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Leaky Gut Syndrome can be caused or aggravated by Candida overgrowth in the gutCandida species that grow hyphae (long, thin germ tubes) may be a factor in causing or aggravating leaky gut syndrome.  The hyphal growths of various Candida species have been proven to elevate their virulence and ability to invade other sectors of the body.  These hyphae can burrow into the walls of the intestines.  Additionally, Candida also secretes an enzyme that breaks down the protective layers of mucous that typically form a chemical barrier between the food and microbiota that travel through the intestines.  By attaching itself to the mucous membranes of the intestines, dissolving the protective mucous, and drilling holes into the intestinal wall, Candida may instigate leaky gut syndrome or aggravate this condition.

The toxins Candida yeast create also may weaken the immune system; this speculation was made by a study published in Contributions to Microbiology and Immunology [4 (1976): 77-85].  With the physical progress yeast can make through the gut into the bloodstream, and the potential stymying of the immune system via toxins, Candida may be a significant detriment to health.  Other substances such as partially digested food and microorganisms may also follow through the breaches Candida makes in the intestinal wall.  This could in turn result in various allergic reactions and bacterial infections throughout the body.

Inflammation and Leaky Gut Syndrome

Inflammation of the intestinal walls can cause the tiny pores that normally allow digested nutrients into the bloodstream to widen.  Once these pores become too big, food, bacteria, and yeast can start to slip through and enter the bloodstream.  According to a study published in Current Opinion in Microbiology [14.4 (2011): 386-391], inflammation increases Candida overgrowth; and, Candida overgrowth worsens inflammation.  According to the study:

Since inflammation increases the likelihood of significant Candida colonization and Candida colonization reduces healing of lesions, these effects would produce a vicious cycle. The presence of inflammation alters bacterial colonization and the activities of the host, creating conditions that favor both high level Candida colonization and exacerbation of disease.
Candida can play a part in weakening intestinal barriers and cause leaky gut syndrome

Consequently, Candida can start a terrible cycle into motion in the digestive system: prompting inflammation and spreading to the newly inflamed areas.  The only way to effectively stop this is to eliminate the overgrowth of yeast in the gut.  This should reduce the size of the pores in the intestines and help to stop leaky gut syndrome.  

Candida Degradates Intestinal Surfaces

A study, published in Infection and Immunity [64.11 (1996): 4514-4519], found that Candida albicans was able to break down the mucin produced by the intestinal mucous membranes with a proteinase enzyme (an enzyme that can break down certain proteins).  The researchers speculated that this was a key element in how Candida albicans was able to break through the chemical barrier provided by mucins surrounding the intestine’s epithelial walls.  The researchers in the study cited various research that proved Candida albicans secretes an enzyme which breaks down proteins and can degredate epithelial keratin (a protein which protects epithelial cells), dermal collagen (the intestines contain collagen as well), albumin (the main protein in human blood), hemoglobin (protein which carries oxygen), and immunoglobulin A (an antibody that plays a critical role in mucosal immunity).

Another study, published in FEMS Microbiology Letters [153.2 (1997): 349-355], showed that Candida albicans was able to break down the endothelium.  The endothelium is a thin layer of flat epithelial cells that lines the lymph vessels, blood vessels, and the inner cavities of the heart.  Thus, given its ability to break down this layer of cells, it could enter through the epithelium (a layer of cells surrounding the outer part of the intestinal wall), break down the endothelium, and enter into the bloodstream.  The researchers stated the following:

Candida albicans infections in severely immunocompromised patients are not confined to mucosal surfaces; instead the fungus can invade through epithelial and endothelial layers into the bloodstream and spread to other organs, causing disseminated infections with often fatal outcome… Our results demonstrate that the C. albicans acid proteinase degrades human subendothelial extracellular matrix; this may be of importance in the penetration of C. albicans into circulation and deep organs.
Some Candida species can grow hyphae and are more virulent than single celled yeast spores

Another study, conducted on mice by giving them intestinal yeast infections, was published in Medical mycology [42.5 (2004): 439-447].  The study used two primary types of Candida albicans: strains that could produce normal hyphal growth, and strains that failed to produce normal hyphal growth.  The study found that the strains that could produce germ tube hyphae were much more virulent.  The strains capable of normally forming hyphae would kill the mice they were tested on and could travel from the intestines to other organs in the mice.  Some of the mice with the virulent hyphal strains of Candida albicans died from Candida colonizing their kidneys.  The reduced presence of hyphal growth deficient yeast in examined mice body tissue and lack of colonization efficacy was suggested by the researchers to potentially be due to the lack of adequate hyphal growth.  Hyphal growth deficient yeast were also unable to kill the mice after they were inoculated.  Consequently, this study proves that Candida albicans can move from the gut to other areas of the body; likely due to its ability to burrow into the walls of the intestines with hyphal growths.

A diagram of the intestinal lumen and surrounding tissue--which Candida albicans is able to penetrate.
A Diagram of the Intestinal Wall Tissues

Hyphal Candida Species

Not all species of Candida grow hyphae.  Some are dimorphic, meaning they exist as single cells (blastoconidia) and as germ tubes (hyphae).  Before 1995, all germ tube positive Candida species were identified as Candida albicans. According to a study published in Indian Journal of Pathology and Microbiology [40 (1997): 55-58], Candida albicans and Candida parapsilosis show very strong hyphal growth.  The following species form hyphae and are more virulent than Candida species that do not form hyphae:

  • Candida albicans
  • Candida tropicalis
  • Candida parapsilosis
  • Candida dubliniensis

Sarah Summer’s 12 Hour Cure for Yeast Infections

Sarah Summer Yeast Infection Review

Sarah Summer is one woman who had an arduous battle with vaginal Candida outbreaks.  It seemed every time she treated them, they would soon return and interrupt her life yet again.  This cycle of treatment and recurrence went on for some time; until, she developed a particularly severe yeast infection.  

Upon deciding this yeast infection was different from past outbreaks, Sarah quickly went to her doctor for help.  Her doctor, after examining her, told her that the yeast in her vagina had developed into a mold.  This mold had sent out long tendrils into her skin and entrenched itself in her body.  Sarah’s doctor told her that not only was this type of infection difficult to treat, it was impossible to cure.  Faced with a lengthy, perhaps impossible to win, battle with yeast, she decided to look for what answers would avail themselves.

Together with her Husband Robert, the two began to diligently study the various facets of Candidiasis.  Sarah decided to look for the root causes that predisposed her to these outbreaks.  Eventually, Sarah and Robert found out how to address the root causes of Candidiasis and naturally eliminate the yeast in her vagina.  Within a short time of applying this new therapy, Sarah was fully free from Candida.  And, her yeast infections stayed gone.

Sarah decided to publish her findings and share what she learned with others in similar battles with Candida.  She offers an 8 week, 100% money back guarantee on her publication as well.  If you find the book unsatisfactory, you can get all your invested finances back promptly.  Her book is published electronically by a subsidiary of Keynetics Incorporated.  If you’d like to find out more about Sarah, her book, or testimonies of people who’ve used it, you can do so at Sarah’s website.



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